I suppose you know there are some small differences in .htaccess handling when you use litespeed.
I don't see how this would affect the database, but I'm not al Litespeed expert. I will ask our Litespeed specialist when I get the occasion.
We're running Litespeed too and I know I sometimes have to change small things in .htaccess files.
If this happens again, could you test without the .htaccess file?
That's the way I find out if it's related. Then I can bug the experts...